OX2 agonist
Orexin-2 receptor agonist
- The dominant wake signal
- Stabilizes wakefulness
- Replaces the orexin signal lost in narcolepsy type 1
- Cognitive benefits
- synaptic plasticity
- memory consolidation
Drugs with this mechanism (2)
- Orexin A — Wake-promoting hypothalamic peptide (hypocretin); its loss causes narcolepsy.
- Orexin B — Wake-promoting hypothalamic neuropeptide with relative preference for orexin-2 receptors; an endogenous signal, not a prescribed drug.
Self-check
- Which narcolepsy type lacks the orexin signal that OX2 agonism replaces?
Type 1. - Which memory process is listed among OX2-associated cognitive benefits?
Memory consolidation.
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