OX1 antagonist

Orexin-1 receptor antagonist

↓ drug intake
depression-like behavior in rats

Drugs with this mechanism (3)

Daridorexant — Dual orexin antagonist hypnotic with a short half-life for less next-day effect.
Lemborexant — Dual orexin antagonist hypnotic.
Suvorexant — Dual orexin antagonist for sleep-onset and sleep-maintenance insomnia.

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