OX1 agonist
Orexin-1 receptor agonist
- Promotes arousal, motivation and hedonic feeding
- Wakefulness & arousal (OX1 < OX2)
- ↑ hedonic feeding (animal models)
- ↑ physical activity / energy expenditure
- Part of the wake/reward orexin system
Drugs with this mechanism (2)
- Orexin A — Wake-promoting hypothalamic peptide (hypocretin); its loss causes narcolepsy.
- Orexin B — Wake-promoting hypothalamic neuropeptide with relative preference for orexin-2 receptors; an endogenous signal, not a prescribed drug.
Self-check
- Which orexin receptor contributes more to wakefulness: OX1 or OX2?
OX2. - What is the evidence context for increased hedonic feeding through OX1?
Animal models.
All mechanisms · Open OX1 agonist in the interactive console ↗