Osteoclast apoptosis inducer
- Incorporated into a nonhydrolyzable ATP analogue inside osteoclasts → apoptosis
- ↓ bone resorption
- The non-nitrogen bisphosphonate route, distinct from FPPS inhibition
Drugs with this mechanism (1)
- Clodronate — First-generation (non-nitrogen) bisphosphonate.
Self-check
- How do non-nitrogen bisphosphonates trigger osteoclast apoptosis?
Incorporation into a nonhydrolyzable ATP analogue. - Is this osteoclast ATP mechanism the same as FPPS inhibition?
No; it is distinct.
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