NRF2 activator

NRF2 pathway activator

Activates the antioxidant response pathway

Drugs with this mechanism (3)

Dimethyl fumarate — Oral MS drug acting through Nrf2; flushing and lymphopenia are the limiting effects.
Diroximel fumarate — Dimethyl fumarate reformulated for less GI upset; same active metabolite.
Omaveloxolone — NRF2 activator for Friedreich ataxia; the first disease-specific therapy.

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