NRF2 activator
NRF2 pathway activator
- Induces antioxidant and cytoprotective genes
- Anti-inflammatory in multiple sclerosis and mitochondrial disease
Drugs with this mechanism (3)
- Dimethyl fumarate — Oral MS drug acting through Nrf2; limited by flushing and lymphopenia.
- Diroximel fumarate — Dimethyl fumarate reformulated for less GI upset; same active metabolite.
- Omaveloxolone — NRF2 activator for Friedreich ataxia; the first disease-specific therapy.
Self-check
- Which gene programs does NRF2 activation induce?
Antioxidant and cytoprotective genes. - In which conditions is the source's NRF2 anti-inflammatory effect described?
Multiple sclerosis and mitochondrial disease.
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