NPC1L1 inhibitor
NPC1L1 cholesterol transporter inhibitor
- ↓ cholesterol absorption → ↓ LDL
- Additive to statins
- Acts in the gut, not the liver
Drugs with this mechanism (1)
- Ezetimibe — Blocks intestinal cholesterol absorption (NPC1L1); adds to statins.
Self-check
- Where does NPC1L1 inhibition act?
In the gut, not the liver. - Does NPC1L1 inhibition add to statin LDL lowering?
Yes.
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