NOP agonist
Nociceptin receptor agonist
- ↓ dopamine release and context-dependent pain modulation
- Central pro-nociceptive effects
- reduced stress-induced analgesia
- Explored for its potential to separate analgesia from mu-opioid reward
Drugs with this mechanism (1)
- Nociceptin — Endogenous ligand of the NOP opioid-like receptor.
Self-check
- How does NOP activation affect dopamine release?
Decreases it. - How are NOP agonists being explored in relation to mu-opioid reward?
For potentially separating analgesia from mu-opioid reward.
All mechanisms · Open NOP agonist in the interactive console ↗