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Nitric oxide donor

• Angina relief; headache and hypotension
• Fatal hypotension with PDE5 inhibitors

Drugs with this mechanism (5)

• Amyl nitrite — Inhaled nitrate vasodilator ("popper"); a nitric-oxide donor.
• Isosorbide dinitrate — Longer-acting oral nitrate; needs a nitrate-free interval to avoid tolerance.
• Isosorbide mononitrate — Long-acting oral nitrate for angina prophylaxis.
• Nitroglycerin — Fast-acting nitrate vasodilator; sublingual rescue for angina.
• Nitroprusside — Seconds-fast BP control that metabolizes to cyanide.

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