nNOS inhibitor
Neuronal nitric oxide synthase (nNOS) inhibitor
- ↓ NO-mediated neurotransmission and excitotoxic signaling
Drugs with this mechanism (2)
- Paroxetine — Most anticholinergic, sedating SSRI; short half-life, notable discontinuation.
- Paroxetine CR — Controlled-release paroxetine for depression and PMDD; smoother delivery, same withdrawal burden.
Self-check
- What signaling decreases with neuronal nitric-oxide synthase inhibition?
NO-mediated neurotransmission and excitotoxic signaling. - Which listed drug carries the nNOS-inhibitor mechanism?
Paroxetine (PAXIL).
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