NMDA polyamine-site negative modulator
NMDA receptor polyamine-site negative modulator
- Negative modulation at the NMDA receptor polyamine site → reduces receptor activity, proposed to normalize glutamate tone
- A candidate mechanism in alcohol-abstinence therapy
Drugs with this mechanism (1)
- Acamprosate — Glutamate-modulating agent for maintaining alcohol abstinence; renally cleared.
Self-check
- What effect is proposed from negative modulation at the NMDA polyamine site?
Reduced receptor activity to normalize glutamate tone. - In which therapy is NMDA polyamine-site modulation a candidate mechanism?
Alcohol-abstinence therapy.
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