NMDA glycine-site partial co-agonist
NMDA glycine partial co-agonist
- Glycine-site occupancy is obligatory for NMDA activation
- Tunes NMDA function up or down depending on ambient co-agonist tone
- The rationale for fear-extinction augmentation
- A function of cycloserine (Seromycin) – D-alanine analog antibiotic; investigated across psychiatric indications
Drugs with this mechanism (1)
- Cycloserine — Second-line tuberculosis antibiotic; NMDA activity drives severe neuropsychiatric toxicity.
Self-check
- What determines whether glycine-site partial co-agonism tunes NMDA function up or down?
Ambient co-agonist tone. - Which learning process motivates this partial co-agonist approach?
Fear-extinction augmentation.
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