NMDA glycine-site antagonist
NMDA receptor glycine-site antagonist
- Glutamate cannot open the channel without glycine-site occupancy
- A different NMDA brake from pore blockers
- Felbamate; kynurenic acid is the endogenous ligand
Drugs with this mechanism (2)
- Felbamate — Broad anticonvulsant restricted for aplastic anemia and hepatotoxicity.
- Kynurenic acid — Endogenous NMDA glycine-site antagonist and tryptophan metabolite.
Self-check
- Can glutamate open the NMDA channel without glycine-site occupancy?
No. - Which endogenous ligand is listed for NMDA glycine-site antagonism?
Kynurenic acid.
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