NHE3 inhibitor
NHE3 sodium-hydrogen exchanger inhibitor
- ↑ luminal sodium/water → softer stool
- ↓ intestinal phosphate absorption
Drugs with this mechanism (1)
- Tenapanor — NHE3 inhibitor for IBS-C and hyperphosphatemia; acts entirely in the gut lumen.
Self-check
- How does NHE3 inhibition soften stool?
Increases luminal sodium and water. - Which mineral's intestinal absorption also falls with NHE3 inhibition?
Phosphate.
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