Nav1.8 blocker

Nav1.8 nociceptor-selective blocker

Nav1.8 nociceptor-selective blocker — mechanism peg (Ballicules) — Nav1.8 blocker — mechanism card

Suppresses peripheral pain signaling
No CNS or opioid effects
Suzetrigine

Drugs with this mechanism (1)

Suzetrigine — First-in-class Nav1.8 blocker; a non-opioid analgesic for acute pain.

Self-check

Where does Nav1.8 blockade suppress pain signaling?
In the periphery.
Does Nav1.8 blockade have CNS or opioid effects here?
Neither.

All mechanisms · Open NaV1.8 blocker in the interactive console ↗