Late Na current blocker
Late sodium current blocker
- Blocks the persistent late sodium current that lingers after the spike
- Stabilizes hyperexcitable tissue without slowing normal conduction
- Blocks the persistent late sodium current after the spike
Drugs with this mechanism (5)
- Cenobamate — Sodium-channel anticonvulsant for refractory focal seizures; slow titration avoids DRESS.
- Lacosamide — Slow-inactivation sodium-channel anticonvulsant; dizziness and PR prolongation.
- Lacosamide ER — Once-daily lacosamide for focal seizures; enhances slow sodium-channel inactivation and can prolong the PR interval.
- Ranolazine — Late-sodium-current blocker for chronic angina; no heart-rate or BP effect.
- Riluzole — Glutamate modulator that modestly prolongs survival in ALS.
Self-check
- Which part of the sodium current is targeted by a late-current blocker?
The persistent current that lingers after the spike. - Does late-current blockade slow normal conduction in the described effect?
No; it stabilizes hyperexcitable tissue without doing so.
All mechanisms · Open NaV late-current blocker in the interactive console ↗