NADPH: reductases
- Maintains antioxidant defense and drug metabolism
- Glutathione reductase, thioredoxin reductase, CYP450 reductase draw on this NADPH pool
- G6PD deficiency starves this supply → oxidative hemolysis
Drugs with this mechanism (1)
- NADP — Phosphorylated NAD coenzyme; its reduced form, NADPH, supports biosynthesis and antioxidant defenses.
Self-check
- Why can G6PD deficiency cause oxidative hemolysis?
It starves the NADPH supply. - Which two broad functions draw on this NADPH pool?
Antioxidant defense and drug metabolism.
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