NAD: PARP
- Poly(ADP-ribose) chains built from NAD⁺ recruit repair proteins to DNA breaks
- PARP consumes NAD⁺ to build these chains
- Repair activity can drain the NAD pool during heavy DNA damage
- Connects genotoxic stress to metabolic depletion
Drugs with this mechanism (1)
- NAD — Niacin-derived coenzyme central to cellular redox reactions; also consumed by enzymes involved in DNA repair and signaling.
Self-check
- How does PARP activity recruit repair proteins to DNA breaks?
Builds poly(ADP-ribose) chains from NAD⁺. - What can heavy DNA damage do to the NAD pool?
Repair activity can drain it.
All mechanisms · Open NAD: PARP in the interactive console ↗