NAD: sirtuins
- Sirtuins use NAD⁺ to deacetylate histones and metabolic proteins
- Links cellular energy state to gene regulation and aging pathways
- Consumed, not just cycled, in these reactions
Drugs with this mechanism (1)
- NAD — Niacin-derived coenzyme central to cellular redox reactions; also consumed by enzymes involved in DNA repair and signaling.
Self-check
- Is NAD⁺ merely recycled during sirtuin reactions?
No; it is consumed. - What do sirtuins deacetylate using NAD⁺?
Histones and metabolic proteins.
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