NAD: dehydrogenases
- Drives glycolysis and the TCA (tricarboxylic acid) cycle
- NAD⁺ is the hydride acceptor of catabolism, including beta-oxidation
- NADH feeds the electron transport chain → ATP
- Derived from niacin (vitamin B3)
- Pellagra = the systemic failure of that electron bookkeeping
Drugs with this mechanism (1)
- NAD — Niacin-derived coenzyme central to cellular redox reactions; also consumed by enzymes involved in DNA repair and signaling.
Self-check
- Which vitamin supplies NAD⁺?
Niacin (vitamin B3). - Where does NADH feed electrons to support ATP production?
The electron transport chain.
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