Neuronal nAChR partial agonist
Neuronal nicotinic acetylcholine receptor partial agonist
- Blocks full nicotine binding
- ↓ craving and ↓ reward from smoking
- Nausea
- Vivid dreams, insomnia
Drugs with this mechanism (1)
- Varenicline — Nicotinic partial agonist; the most effective single agent for smoking cessation.
Self-check
- How does neuronal nicotinic partial agonism affect smoking reward?
Reduces it, along with craving. - Which sleep effects can accompany neuronal nicotinic partial agonism?
Vivid dreams and insomnia.
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