Cardiac myosin inhibitor
- Directly reduces cardiac myosin-actin cross-bridging → ↓ hypercontractility
- Relieves outflow obstruction in hypertrophic cardiomyopathy
- Over-inhibition → systolic dysfunction; ejection fraction monitoring
Drugs with this mechanism (2)
- Aficamten — Shorter-acting cardiac myosin inhibitor for obstructive HCM; echo monitoring guards against systolic failure.
- Mavacamten — Cardiac myosin inhibitor for obstructive hypertrophic cardiomyopathy (adults and children ≥30 kg).
Self-check
- Which obstruction can cardiac myosin inhibition relieve?
Outflow obstruction in hypertrophic cardiomyopathy. - Why monitor ejection fraction with cardiac myosin inhibition?
Over-inhibition can cause systolic dysfunction.
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