Myosin activator
Cardiac myosin activator
- Prolongs systolic ejection
- Directly activates cardiac myosin
- Improves contractility without raising cardiac calcium or oxygen demand
- Excessive dosing lengthens systole → myocardial ischemia
Drugs with this mechanism (1)
- Omecamtiv mecarbil — Investigational cardiac myosin activator for reduced-EF heart failure; enhances contraction without directly increasing intracellular calcium.
Self-check
- Must cardiac myosin activation raise cardiac calcium or oxygen demand to improve contractility?
No. - Why can excessive myosin-agonist dosing cause ischemia?
It lengthens systole excessively.
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