Mineralocorticoid antagonist
Mineralocorticoid receptor antagonist
- Potassium-sparing diuresis; mortality benefit in heart failure
- Hyperkalemia is the principal danger
Drugs with this mechanism (4)
- Drospirenone — Antimineralocorticoid progestin used in contraceptives.
- Eplerenone — Selective mineralocorticoid antagonist; less gynecomastia than spironolactone.
- Finerenone — Nonsteroidal MRA with renal and cardiovascular benefit in diabetic kidney disease.
- Spironolactone — Aldosterone antagonist; heart-failure survival, acne, and gynecomastia.
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