Microtubule stabilizer
- Prevents microtubule disassembly → freezes cells in mitosis
- Cytotoxicity in solid tumors
- Disrupted axonal transport → peripheral neuropathy
- Neutropenia
- Hypersensitivity to the solubilizing vehicle
Drugs with this mechanism (1)
- Paclitaxel — Taxane chemotherapy that stabilizes microtubules; neuropathy often limits treatment.
Self-check
- Why can microtubule stabilizers cause peripheral neuropathy?
They disrupt axonal transport. - What happens to mitosis when microtubule disassembly is prevented?
Cells freeze in mitosis.
All mechanisms · Open Microtubule stabilizer in the interactive console ↗