Fungal microtubule inhibitor
- Disrupts the fungal mitotic spindle
- Arrests fungal cell division → fungistatic
- Requires prolonged exposure
Drugs with this mechanism (1)
- Griseofulvin — Oral antifungal for dermatophytes; deposits in keratin, long courses.
Self-check
- Which fungal structure is disrupted by microtubule inhibition?
The mitotic spindle. - Is fungal microtubule inhibition fungicidal or fungistatic?
Fungistatic; it arrests cell division.
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