mGluR antagonist
Metabotropic glutamate receptor antagonist
- Would modulate glutamatergic tone rather than block fast excitatory transmission
Drugs with this mechanism (1)
- Acamprosate — Glutamate-modulating agent for maintaining alcohol abstinence; renally cleared.
Self-check
- Would mGluR antagonism directly block fast excitatory transmission?
No; it would modulate glutamatergic tone. - Which listed drug carries the mGluR-antagonist mechanism?
Acamprosate (CAMPRAL).
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