mGluR agonist
Metabotropic glutamate receptor agonist
- G-protein-coupled, not ionotropic
- Modulates transmitter release and excitability rather than fast transmission
- A slower, tuning layer over glutamate signaling
- Glutamate is the only relevant agonist
Drugs with this mechanism (2)
- Aspartate — Excitatory amino acid and NMDA-receptor agonist.
- Glutamate — Primary excitatory CNS neurotransmitter.
Self-check
- Are metabotropic glutamate receptors ion channels?
No; they are G-protein-coupled. - Does mGluR activation mediate fast transmission?
No; it modulates transmitter release and excitability.
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