Metal chelator
Polyvalent metal chelator (antifungal)
- Chelates polyvalent metals required by fungal metalloenzymes
- Inhibits fungal metabolism — distinct from ergosterol-synthesis blockade
- Broad topical antifungal/antibacterial action
Drugs with this mechanism (1)
- Ciclopirox — Non-azole topical antifungal; nail lacquer cures onychomycosis poorly.
Self-check
- Why does metal chelation inhibit fungal metabolism?
It chelates polyvalent metals required by fungal metalloenzymes. - Is metal chelation the same as blocking ergosterol synthesis?
No; it is a distinct mechanism.
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