Metabolism & half-life
- The center hole sizes CYP substrate sensitivity, tiny to gigantic, locked to the single most consequential enzyme — never enlarged by listing more.
Not a mechanism or drug peg. This card explains the central donut hole — CYP sensitivity, not a receptor target.
Self-check
- What does the center-hole size encode?
CYP substrate sensitivity. - Does listing more enzymes enlarge the center hole?
No; sizing uses the single most consequential enzyme.