LPS membrane disruptor
Bacterial LPS membrane disruptor
- Membrane leakage → bacterial death
- Disrupts the bacterial outer membrane — the polymyxins
- A last-resort agent for resistant Gram-negatives
- Nephro- and neurotoxicity
Drugs with this mechanism (1)
- Polymyxin B — Cationic detergent antibiotic that disrupts gram-negative outer membranes.
Self-check
- Which bacteria are targeted by last-resort polymyxin use described here?
Resistant Gram-negatives. - Which two organ-system toxicities are described for polymyxins?
Nephrotoxicity and neurotoxicity.
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