InhA inhibitor
Mycobacterial InhA (mycolic acid synthesis) inhibitor
- Mycolic-acid synthesis fails and the mycobacterial cell wall collapses
- Selective for mycobacteria
- Hepatotoxicity; B6 depletion causes neuropathy
Drugs with this mechanism (1)
- Isoniazid — First-line tuberculosis drug; hepatotoxicity and pyridoxine-responsive neuropathy shape use.
Self-check
- Which cell-wall component fails to be synthesized with InhA inhibition?
Mycolic acid. - Which deficiency causes the neuropathy described with InhA inhibition?
Vitamin B6 depletion.
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