IGF-1 GPE analogue
IGF-1 tripeptide (GPE) analogue
- Modulates synaptic and glial signaling → improves Rett syndrome
- Acts WITHOUT binding the IGF-1 receptor
- IGF-1 tripeptide (GPE) analogue
Drugs with this mechanism (1)
- Trofinetide — IGF-1-derived tripeptide analog for Rett syndrome; diarrhea and weight loss often limit use.
Self-check
- Does the GPE analogue act by binding the IGF-1 receptor?
No. - Which syndrome improves through the described synaptic and glial signaling effects?
Rett syndrome.
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