Capsid inhibitor
HIV capsid inhibitor
- Disrupts uncoating, nuclear import and assembly
- Active against virus resistant to other antiretroviral classes
Drugs with this mechanism (2)
- Lenacapavir — First-in-class HIV capsid inhibitor; twice-yearly dosing for treatment and prevention.
- Lenacapavir (PrEP) — Long-acting capsid inhibitor for HIV PrEP; infrequent injections remove daily adherence.
Self-check
- Name a viral stage disrupted by HIV capsid inhibition besides assembly.
Uncoating or nuclear import. - Can HIV capsid inhibition act against virus resistant to other antiretroviral classes?
Yes.
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