NS3/4A protease inhibitor
Hepatitis C NS3/4A protease inhibitor
- Polyprotein cannot be cleaved
- A backbone of curative direct-acting antiviral regimens
- The “-previr” class
- Combined with agents of other classes to prevent resistance
Drugs with this mechanism (4)
- Glecaprevir — Hepatitis C NS3/4A protease inhibitor.
- Grazoprevir — Hepatitis C NS3/4A protease inhibitor coformulated with elbasvir; avoid in decompensated liver disease.
- Paritaprevir — Hepatitis C NS3/4A protease inhibitor.
- Simeprevir — Older hepatitis C NS3/4A protease inhibitor; photosensitivity, rash, and substantial interaction burden.
Self-check
- Which viral processing step fails with HCV NS3 protease inhibition?
Polyprotein cleavage. - Why combine HCV NS3 inhibitors with other antiviral classes?
To prevent resistance.
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