NS3/4A protease inhibitor
Hepatitis C NS3/4A protease inhibitor
- Blocks hepatitis C polyprotein cleavage
- Part of curative combination regimens
Drugs with this mechanism (4)
- Glecaprevir — Hepatitis C NS3/4A protease inhibitor.
- Grazoprevir — Hepatitis C NS3/4A protease inhibitor coformulated with elbasvir; avoid in decompensated liver disease.
- Paritaprevir — Hepatitis C NS3/4A protease inhibitor.
- Simeprevir — Older hepatitis C NS3/4A protease inhibitor; photosensitivity, rash, and substantial interaction burden.
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