HCN4 blocker
HCN4 funny-current blocker
- ↓ heart rate without reducing contractility or blood pressure
- Slows the sinus node funny current
- Visual phosphenes from retinal HCN
Drugs with this mechanism (1)
- Ivabradine — HCN "funny current" blocker; slows heart rate without affecting contractility.
Self-check
- Does HCN4 blockade lower contractility along with heart rate?
No; contractility and blood pressure are preserved. - Why can HCN4 blockade cause visual phosphenes?
Retinal HCN effects.
All mechanisms · Open HCN4 blocker in the interactive console ↗