Guanylate cyclase C agonist
- ↑ intestinal cGMP
- Chloride/bicarbonate and water secretion → relieves constipation
- Also quiets visceral afferents → abdominal-pain benefit in IBS-C
- Diarrhea
- Contraindicated in children
Drugs with this mechanism (2)
- Linaclotide — Guanylate cyclase-C agonist for constipation-predominant IBS.
- Plecanatide — Uroguanylin-analog guanylate cyclase-C agonist for chronic constipation and IBS-C.
Self-check
- What explains abdominal-pain benefit in IBS-C beyond increased secretion?
Quieting visceral afferents. - What adverse effect accompanies intestinal guanylate cyclase C agonism?
Diarrhea.
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