GnRH receptor agonist
- Continuous stimulation desensitizes the receptor, suppressing gonadotropins
- Initial testosterone surge — a tumor flare risk in prostate cancer
Drugs with this mechanism (2)
- Goserelin — GnRH receptor AGONIST implant; flare first, then downregulation.
- Leuprolide — GnRH agonist causing an initial flare then suppression of sex hormones.
All mechanisms · Open the interactive console ↗