Glycine receptor partial agonist
- Cl⁻ influx → hyperpolarization, chiefly in spinal cord and brainstem
- Reduces neuronal excitability
- Neuroprotection
Drugs with this mechanism (1)
- Taurine — Endogenous amino acid; a glycine/GABA-A modulator and common supplement.
Self-check
- Which membrane change follows chloride influx with partial GlyR agonism?
Hyperpolarization. - Where does this partial GlyR effect chiefly occur?
Spinal cord and brainstem.
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