Glycine receptor antagonist
- Unopposed motor-neuron firing → rigidity and seizures
- Spasms with a clear sensorium — spinal, not cortical
- Strychnine, picrotoxin
Drugs with this mechanism (1)
- Strychnine — Glycine-receptor antagonist convulsant poison.
Self-check
- What happens to sensorium during the characteristic spinal spasms of GlyR blockade?
It remains clear. - What motor-neuron change causes rigidity and seizures with GlyR blockade?
Unopposed firing.
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