Glutamate release inhibitor
- Less excitotoxic drive — modest survival benefit in ALS
- Reduces persistent sodium current
Drugs with this mechanism (1)
- Riluzole — Glutamate modulator that modestly prolongs survival in ALS.
Self-check
- How large is the described ALS survival benefit of glutamate-release inhibition?
Modest. - Which sodium current is reduced alongside glutamate release?
Persistent sodium current.
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