Kainate receptor negative allosteric modulator
- ➔ dampens glutamate overactivity → antiepileptic and anti-craving effect
Drugs with this mechanism (3)
- Topiramate ER (sprinkle) — Sprinkle-capsule extended-release topiramate for epilepsy and migraine prevention.
- Topiramate — Weight-reducing anticonvulsant for seizures and migraine; cognitive slowing limits it.
- Topiramate ER — Extended-release topiramate for seizures; cognitive slowing, kidney stones and fetal oral clefts.
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