Glucocorticoid receptor modulator
- Dissociated steroid biases signaling toward transrepression (anti-inflammatory) over transactivation (metabolic)
- Anti-inflammatory benefit with less growth suppression and bone toxicity
- Vamorolone in Duchenne muscular dystrophy
Drugs with this mechanism (1)
- Vamorolone — Dissociative glucocorticoid-receptor modulator for Duchenne dystrophy; still suppresses the adrenal axis.
Self-check
- Which signaling mode does a dissociated glucocorticoid modulator favor?
Anti-inflammatory transrepression over metabolic transactivation. - Which disease is the supplied vamorolone example for?
Duchenne muscular dystrophy.
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