Glutamate-gated Cl channel agonist
Invertebrate glutamate-gated chloride channel agonist
- Hyperpolarization → parasite paralysis
- Kills nematodes and arthropods
- Mammals lack the channel
- The blood-brain barrier also excludes it
Drugs with this mechanism (1)
- Ivermectin — Antiparasitic opening invertebrate glutamate-gated chloride channels.
Self-check
- How does opening parasite glutamate-gated chloride channels cause paralysis?
Hyperpolarization. - Why does this target help spare mammals?
Mammals lack the channel.
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