Glucagon receptor agonist
- ↑ hepatic glycogenolysis and gluconeogenesis
- Raises blood glucose — rescue for severe hypoglycemia (unless paired with GLP-1/GIP agonism)
- Relaxes GI smooth muscle
- Supports inotropy in beta-blocker overdose
- ↑ energy expenditure and hepatic fat oxidation
- Nausea and vomiting
Drugs with this mechanism (2)
- Glucagon — Counter-regulatory hormone; rescue for severe hypoglycemia and beta-blocker overdose.
- Retatrutide — Investigational triple GIP/GLP-1/glucagon agonist for obesity.
Self-check
- Which hepatic processes are increased by glucagon-receptor agonism?
Glycogenolysis and gluconeogenesis. - In which overdose can glucagon support inotropy?
Beta-blocker overdose.
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