GH receptor antagonist
Growth hormone receptor antagonist
- ↓ IGF-1 production
- Controls acromegaly regardless of tumor somatostatin receptors
- GH levels RISE on treatment — follow IGF-1, not GH
Drugs with this mechanism (1)
- Pegvisomant — Growth hormone RECEPTOR antagonist: IGF-1 falls while measured GH rises.
Self-check
- Which marker should guide GH-receptor antagonist treatment: GH or IGF-1?
IGF-1; GH rises during treatment. - Does acromegaly control by GH-receptor blockade depend on tumor somatostatin receptors?
No.
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