G-CSF agonist

G-CSF receptor agonist

G-CSF receptor agonist — mechanism peg (Ballicules) — G-CSF agonist — mechanism card

Neutrophil production accelerates → shortens chemotherapy neutropenia
Mobilizes hematopoietic stem cells into peripheral blood
Marrow expansion → bone pain
Rare splenic rupture

Drugs with this mechanism (2)

Filgrastim — Recombinant G-CSF that shortens chemotherapy-induced neutropenia.
Pegfilgrastim — Long-acting G-CSF agonist preventing febrile neutropenia after myelosuppressive chemotherapy.

Self-check

Where does G-CSF mobilize hematopoietic stem cells?
Into peripheral blood.
What mechanism explains G-CSF-associated bone pain?
Marrow expansion.

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