GAT-1 inhibitor
GABA transporter 1 reuptake inhibitor
- Synaptic GABA persists
- off-label for social anxiety disorder
- may alter color perception ◇ brighter blues/greens ◇ via GABA-C receptors in retina
- ↑ inhibitory signaling → antiseizure effect
- Can provoke absence-type spike-wave events — the wrong seizure types worsen
Drugs with this mechanism (1)
- Tiagabine — GAT-1 inhibitor that raises synaptic GABA; adjunctive anticonvulsant with paradoxical seizure risk.
Self-check
- What happens to synaptic GABA after GAT-1 inhibition?
It persists longer. - Which seizure pattern can GAT-1 inhibition provoke?
Absence-type spike-wave events.
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