GABA-A channel blocker

GABA-A receptor channel blocker

Neuronal overstimulation → seizures
Pentetrazol – used to induce seizures for shock therapy in the 1930s prior to debut of electroconvulsive therapy (1938)
Flurothyl - used experimentally (by inhalation) for shock therapy in 1953 as an alternative to ECT
Picrotoxin (from certain berries)
Thujone (from wormwood, sage)
➔ flavoring component of absinthe

Drugs with this mechanism (1)

Picrotoxin — Plant convulsant that blocks the GABA-A chloride channel; a laboratory tool, not a medicine.

All mechanisms · Open the interactive console ↗