GABA transaminase inhibitor
- ↓ GABA degradation
- ↑ brain GABA → antiseizure effect
- Permanent visual-field loss — monitoring required
- Valproate inhibits only indirectly, not at therapeutic concentrations
Drugs with this mechanism (1)
- Vigabatrin — Irreversible GABA-transaminase inhibitor; irreversible visual field loss.
Self-check
- What potentially permanent toxicity requires monitoring with GABA-transaminase inhibition?
Visual-field loss. - How does increased brain GABA affect seizure activity?
It produces an antiseizure effect.
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