Formaldehyde releaser
Formaldehyde-releasing urinary antiseptic
- Nonspecific antimicrobial denaturation
- Suppression of recurrent UTI, not acute infection
- Requires acidic urine — fails with urease-producing organisms (Proteus)
- No acquired bacterial resistance
Drugs with this mechanism (2)
- Methenamine hippurate — Urinary antiseptic that releases formaldehyde in acidic urine.
- Methenamine mandelate — Urinary antiseptic releasing formaldehyde in acidic urine.
Self-check
- Is formaldehyde-releasing urinary antisepsis intended for acute infection?
No; suppression of recurrent UTI. - Which urine condition is required for this mechanism?
Acidic urine.
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